Open AccessAssociation study of APOE, LPL and NOS3 polymorphisms with the risk of common cardio pathology in children and pregnant women
Author(s) -
Andrey S. Glotov,
Elena S. Vashukova,
Maria D Kanaeva,
Maria O Dvoeglazova,
Maria M. Danilova,
Vladimir S. Pakin,
Ekaterina Yu Marochkina,
Dina Rustemovna Bicmullina,
Maria A Glebova,
Ирина Александровна Махрова,
Г. И. Образцова,
Oleg S. Glotov,
М. С. Зайнулина,
Т. Э. Иващенко,
Vladislav Baranov
Publication year - 2011
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen9425-34
Subject(s) - preeclampsia , genotype , medicine , pregnancy , obesity , apolipoprotein e , endocrinology , polymorphism (computer science) , physiology , obstetrics , biology , genetics , gene , disease
Polymorphisms of APOE (E2/E3/E4), LPL (1595C>G) and NOS3 (-786T>C) in groups of pregnant women with and without preeclampsia, in donors, in children with hypertension, children with obesity and metabolic syndrome, and in control children were studied by PCR /RF LP analysis. Statistically significant increase of T/C genotype frequency of NOS3 in pregnant women with preeclampsia as well as in women with physiological pregnancy compared to this one in nonpregnant women of donors group was assessed (56%, 59% and 37%, respectively, F<0.03).