Open AccessGeograpahic distribution of allele frequencies of alcohol metabolism genes and possible determinants of inter population diversity in human
Author(s) -
S. A. Borinskaya,
Боринская Светлана Александровна,
Nina Kal'ina,
Кальина Нина Ромуальдовна,
Vyacheslav Ivanovich Shirmanov,
Ширманов Вячеслав Иванович,
В. А. Кошечкин,
Кошечкин Владимир Анатольевич,
Nikolay K Yankovsky,
Янковский Николай Казимирович
Publication year - 2011
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen9347-56
Subject(s) - adh1b , allele , genetics , allele frequency , biology , gene , ethanol metabolism , aldh2 , alcohol consumption , population , enzyme , alcohol , medicine , environmental health , biochemistry , branched chain alpha keto acid dehydrogenase complex , dehydrogenase
ADH1B and ALDH2 genes are coding for key alcohol metabolism enzymes. Both allele ADH1B*Arg48His and ALDH2*504Lys are associated with lower alcohol consumption level. The allele frequencies were determined for rather few populations of Russia. The article presents аn updated review on the allele frequencies worldwide including the data for populations of Russia which were determined by our lab in recent years. Possible role of factors influencing the peculiarities of ADH1B*48His and ALDH2*504Lys allele frequencies geographic distribution are being discussed.