Methylation anomalies in cancerogenesis: search for new genes, development of methods and DNA-markers for diagnosis | Zendy

Zaletaev Dv | Zendy; V. V. Strelnikov | Zendy; Т. В. Кекеева | Zendy; В В Землякова | Zendy; Ekaterina Kuznetsova | Zendy; Dmitri S Mikhaylenko | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Methylation anomalies in cancerogenesis: search for new genes, development of methods and DNA-markers for diagnosis

Author(s) -

Zaletaev Dv,

V. V. Strelnikov,

Т. В. Кекеева,

В В Землякова,

Ekaterina Kuznetsova,

Dmitri S Mikhaylenko

Publication year - 2011

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen9327-32

Subject(s) - epigenetics , methylation , dna methylation , biology , gene , genetics , suppressor , tumor suppressor gene , microbiology and biotechnology , cancer research , carcinogenesis , gene expression

The report considers the epigenetic defects and their diagnostics in tumors. Aberrant methylation of the promoter or regulatory region of a gene results in its functional inactivation, which is phenotypically similar to structural deletion. Cancerogenesis-associated genes are often methylated in tumors. Tumors differ in methylation frequencies, allowing differential diagnostics. Aberrant methylation of tumor suppressor genes occurs in early cancerogenesis, and its detection may be employed in presymptomatic and noninvasive diagnostics of tumors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research