Open AccessMethylation anomalies in cancerogenesis: search for new genes, development of methods and DNA-markers for diagnosis
Author(s) -
D. V. Zaletaev,
В. В. Стрельников,
Т. В. Кекеева,
В В Землякова,
Е. Б. Кузнецова,
Dmitri S Mikhaylenko
Publication year - 2011
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen9327-32
Subject(s) - epigenetics , methylation , dna methylation , biology , gene , genetics , suppressor , tumor suppressor gene , microbiology and biotechnology , cancer research , carcinogenesis , gene expression
The report considers the epigenetic defects and their diagnostics in tumors. Aberrant methylation of the promoter or regulatory region of a gene results in its functional inactivation, which is phenotypically similar to structural deletion. Cancerogenesis-associated genes are often methylated in tumors. Tumors differ in methylation frequencies, allowing differential diagnostics. Aberrant methylation of tumor suppressor genes occurs in early cancerogenesis, and its detection may be employed in presymptomatic and noninvasive diagnostics of tumors.