The influence of D. melanogaster mutations of the kynurenine pathway of tryptophan metabolism on locomotor behavior and expression of genes belonging to glutamatergic and cholinergic systems | Zendy

Gennady A. Zakharov | Zendy; А. В. Журавлев | Zendy; Tatyana L Payalina | Zendy; Н. Г. Камышев | Zendy; Е. В. Савватеева-Попова | Zendy

Open Access

The influence of D. melanogaster mutations of the kynurenine pathway of tryptophan metabolism on locomotor behavior and expression of genes belonging to glutamatergic and cholinergic systems

Author(s) -

Gennady A. Zakharov,

А. В. Журавлев,

Tatyana L Payalina,

Н. Г. Камышев,

Е. В. Савватеева-Попова

Publication year - 2011

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen9265-73

Subject(s) - ionotropic effect , kynurenic acid , kynurenine pathway , glutamatergic , drosophila melanogaster , mutant , kynurenine , biology , cholinergic , genetics , mutation , gene , tryptophan , receptor , microbiology and biotechnology , neuroscience , glutamate receptor , amino acid

Disbalance of kynurenines produced by Drosophila mutations of the kynurenine pathway of tryptophan metabolism influences the locomotor behavior in larvae. The most pronounced is the effect of accumulation of kynurenic acid in the mutant cinnabar manifested as sharp reduction of general level of locomotor activity. The mutations seem to act through modulatory influences of kynurenines on signal cascades governed by ionotropic glutamatergic and cholinergic receptors. Expression of receptor genes in the mutants shows age-related changes pointing to gradual evolvement of consequences of kynurenines disbalance.

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