APOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples | Zendy

А. И. Козлов | Zendy; S. A. Borinskaya | Zendy; E. D. Sanina | Zendy

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APOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples

Author(s) -

А. И. Козлов,

S. A. Borinskaya,

E. D. Sanina

Publication year - 2011

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen9217-23

Subject(s) - westernization , megacity , genotype , indigenous , apolipoprotein e , biology , modernization theory , demography , genetics , gene , medicine , ecology , economic growth , disease , sociology , economics

The prevalence of APOE gene ε4/ε4 genotype in the populations with various level of “westernization” is under the consideration. It is proposed that the populations with a high frequency of *ε4 undergoing “modernization transition” are in the most vulnerable state. These are the Eastern Finns and especially indigenous people of the North, who have a higher level of diseases of circulatory system than megacity residents.

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