Open AccessAPOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples
Author(s) -
А. И. Козлов,
S. A. Borinskaya,
Е. Д. Санина
Publication year - 2011
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen9217-23
Subject(s) - westernization , megacity , genotype , indigenous , apolipoprotein e , biology , modernization theory , demography , genetics , gene , medicine , ecology , economic growth , disease , sociology , economics
The prevalence of APOE gene ε4/ε4 genotype in the populations with various level of “westernization” is under the consideration. It is proposed that the populations with a high frequency of *ε4 undergoing “modernization transition” are in the most vulnerable state. These are the Eastern Finns and especially indigenous people of the North, who have a higher level of diseases of circulatory system than megacity residents.