Open AccessThe role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients
Author(s) -
Nora Babudri,
Alessandro Achilli,
Chiara Martinelli,
Elizabeth A. Moore,
Hovirag Lancioni,
Youri I. Pavlov
Publication year - 2011
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen9153-61
Subject(s) - dna polymerase , biology , mutagenesis , proofreading , dna replication , saccharomyces cerevisiae , polymerase , dna , yeast , genetics , dna repair , mutant , dna polymerase ii , microbiology and biotechnology , gene , polymerase chain reaction , reverse transcriptase
In nature, microorganisms experience numerous environmental stresses and generally grow poorly most of the time. In the last two decades it has become evident that mutations arise not only in actively dividing cells but also in nonreplicating or slowly replicating cells starved for nutrients. In yeast, precise base selection and proofreading by replicative DNA polymerases δ and ε keep starvation-associated mutagenesis (SAM) at basal levels. Less is known about the role of replicative DNA polymerase α (Pol α). Here we provide evidence that Pol α is involved in the control of SAM in yeast cells starved for adenine by participation in sporadic replication and/or DNA repair under these conditions.