Open AccessEpigenetical mechanisms of susceptibility to complex human diseases
Author(s) -
Е. Л. Паткин,
Паткин Евгений Львович,
John P. Quinn,
Квинн Джон
Publication year - 2010
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen8444-56
Subject(s) - epigenetics , biology , inheritance (genetic algorithm) , genetics , tandem repeat , evolutionary biology , mechanism (biology) , dna methylation , computational biology , genome , gene , epistemology , philosophy , gene expression
Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.