Epigenetical mechanisms of susceptibility to complex human diseases | Zendy

Е. Л. Паткин | Zendy; John P. Quinn | Zendy

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Epigenetical mechanisms of susceptibility to complex human diseases

Author(s) -

Е. Л. Паткин,

John P. Quinn

Publication year - 2010

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen8444-56

Subject(s) - epigenetics , biology , inheritance (genetic algorithm) , genetics , tandem repeat , evolutionary biology , mechanism (biology) , dna methylation , computational biology , genome , gene , epistemology , philosophy , gene expression

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

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