Open AccessGenotoxic safety of synthetic food colours. Review
Author(s) -
V. V. Yurchenko,
Faina I. Ingel,
Lyudmila V. Akhaltseva,
Mariya A. Konyashkina,
Nadezda A. Yurtseva,
Tatyana A. Nikitina,
Е. К. Кривцова
Publication year - 2021
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen79399
Subject(s) - genotoxicity , food safety , russian federation , selection (genetic algorithm) , food additive , test (biology) , consumer safety , food products , microbiology and biotechnology , toxicology , risk analysis (engineering) , environmental health , food science , computer science , biology , business , medicine , artificial intelligence , ecology , toxicity , economic policy
Food additives and, in particular, food colours are becoming more widespread in all countries. The review is devoted to the least studied problem of synthetic food colours safety assessment approved for use in the Russian Federation to the analysis of their genotoxic effect (mechanisms, methods of determination and results of studies on various living objects). Presented results of the synthetic food colours genotoxicity half-century study demonstrated that among of studied colours there was none for which unambiguous research results were obtained, that allows us to conclude the possibility of their real mutagenic and/or carcinogenic danger. It is shown that the problem of the dose range selecting for genotoxicity testing, the associated problem of impurities control as well as approaches to test systems and test objects selection are the key to ensuring the genetic/carcinogenic safety of food colours. These problems are aggravated by the fact that in Russian Federation there is no unified system for food colours genetic safety assessing. So the main task of this publication is to prove the urgent necessity for elaboration of this system and outline group of main problems associated therewith.