Open AccessDiludine and cerebrocrast as bioprotectors in the model test-systems in vivo
Author(s) -
Natalia V Savina,
Natalia V. Nikitchenko,
Olga Dalivelya,
Tatyana D. Kuzhir,
Egīls Bisenieks,
G. Duburs,
Р. И. Гончарова
Publication year - 2009
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen7330-43
Subject(s) - in vivo , ethyl methanesulfonate , chemistry , germ cell , biology , toxicology , dominant lethal , mutation , pharmacology , genetics , stereochemistry , biochemistry , gene
An influence of two 1,4-dihydropyridine derivatives (diludine and cerebrocrast) on Drosophiladevelopment and germ cell mutability was studied. It was revealed the concentration range, within which the compounds manifest their bio-stimulating effects increasing individual survival by 50-80 % as well as the protective action against the alkylating agent ethyl methanesulfonate reducing the level of induced mutations by 30-50 %. The pattern and presumable mechanisms of the bioprotective action of these compounds are considered.