Diludine and cerebrocrast as bioprotectors in the model test-systems in vivo | Zendy

Natalia V Savina | Zendy; Natalia V. Nikitchenko | Zendy; Olga Dalivelya | Zendy; Tatyana D. Kuzhir | Zendy; Egīls Bisenieks | Zendy; Г. Дубурс | Zendy; Р. И. Гончарова | Zendy

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Diludine and cerebrocrast as bioprotectors in the model test-systems in vivo

Author(s) -

Natalia V Savina,

Natalia V. Nikitchenko,

Olga Dalivelya,

Tatyana D. Kuzhir,

Egīls Bisenieks,

Г. Дубурс,

Р. И. Гончарова

Publication year - 2009

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen7330-43

Subject(s) - in vivo , ethyl methanesulfonate , chemistry , germ cell , biology , toxicology , dominant lethal , mutation , pharmacology , genetics , stereochemistry , biochemistry , gene

An influence of two 1,4-dihydropyridine derivatives (diludine and cerebrocrast) on Drosophiladevelopment and germ cell mutability was studied. It was revealed the concentration range, within which the compounds manifest their bio-stimulating effects increasing individual survival by 50-80 % as well as the protective action against the alkylating agent ethyl methanesulfonate reducing the level of induced mutations by 30-50 %. The pattern and presumable mechanisms of the bioprotective action of these compounds are considered.

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