Open AccessThe analysis of association of the minisatellite UPS29 with Parkinson's disease
Author(s) -
И. О. Сучкова,
Daria M Shubina,
Andrey F. Yakimovsky,
E. V. Borisova,
Nadezhda G Eliseeva,
Л. К. Сасина,
Т. В. Баранова,
Vladislav Baranov,
Е. Л. Паткин
Publication year - 2009
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen7119-29
Subject(s) - minisatellite , disease , allele , parkinson's disease , genetics , genetic association , biology , medicine , genotype , gene , microsatellite , single nucleotide polymorphism
The aim of this work was to identify new genetic markers associated with different forms of Parkinson's disease. A frequency of occurrence of different allele variants of minisatellite UPS29 localized in intron of centaurin p5 gene (CENTB5) was evaluated for patients with this pathology. The increase of frequency of UPS29 short alleles was observed for Parkinson's disease patients. This value depended on patient sex and age of pathology debut. Statistically significant difference with control was found only for females with early (30-50 years old) and late (> 60 years old) onset of Parkinson's disease. We suppose that UPS29 might be used as new genetic markers forearly (presymptomatic) diagnostics of some forms of Parkinson's disease.