«Ageingfeatures» analysis of IGF-1 and PGC-1 genes polymorphism

Our goal was to investigate whether a polymorphism in IGF-1 gene (wild-type, 192 base pairs) and in the PGC-1 gene (Gly482Ser polymorphism) influence life expectancy. Different distribution of IGF-1 (CA repeats) gene polymorphism was shown. Increasing of 20/- genotype in elderly people compared with newborn group (26,7 and 44,1 %, accordantly, ϰ 2  = 8,57, p = 0,0034) and decreasing of 19/19 genotype (51 and 27,9%, accordantly, ϰ 2  = 14,815, p = 0.0001) were founded. Furthermore, it was shown different distribution of IGF-1 (CA repeats) gene polymorphism in man and woman. It was detected increasing of 19/20 genotype in newborn man compared with newborn woman (23,2 and 11,3%, accordantly), and significantly increasing of 19/20 genotype in elderly man compared with elderly woman (44,4 and 21,1%, accordantly, ϰ 2  = 5,009, p = 0,025). A possible role of IGF-1 gene CA-polymorphism in ageing that is suggested. The prevalent Gly482Ser polymorphism of the PGC-1 gene has not been shown to be associated with life expectancy. It was detected increasing of Gly/Gly genotype in elderly woman compared with elderly man (51,0 и 27,3%, accordantly, ϰ 2  = 4,063, p = 0,0438). The joint contribution of IGF-1 gene and PGC-1 gene is involved in ageing between groups of newborn and elderly people (20%, 41,8%, accordantly, ϰ 2  = 4,858, p = 0,0275).