Open AccessMolecular-genetic characterization of the human non-hypervariable GC-rich minisatellite UPS29 of gene CENTB5
Author(s) -
И. О. Сучкова,
Daria M Shubina,
Л. К. Сасина,
Natalia O Slominska,
V. B. Vasilyev,
Natalia Alenina,
Mikhael F Bader,
Е. Л. Паткин
Publication year - 2007
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen5335-45
Subject(s) - minisatellite , genetics , hypervariable region , biology , loss of heterozygosity , allele , gene , microsatellite , in silico , intron
Human minisatellite UPS29 localized in one of CENTB5 introns was studied in silico and using molecular genetic analysis. For the first time there were revealed seven UPS29 alleles which contained 6-24 repeated units. Allele consisting of 17 repeats was prevailed (91,5 %). Frequency of other alleles varied from 0,29 % to 4,39 %. UPS29 heterozygosity was 12,3 %. Minisatellite UPS29 was classified as low polymorphic and non hypervariable.