Open AccessPart 2. Environmental Factors And Individual Features In System Of Evaluation Of Human Genome Instability. Additional Capability Of The Test The Technique For Cytogenetic Analysis
Author(s) -
Faina I. Ingel
Publication year - 2006
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen4438-54
Subject(s) - genome instability , biology , chromosome instability , genotoxicity , cytochalasin b , computational biology , human blood , test (biology) , genome , genetics , in vitro , physiology , gene , dna , medicine , dna damage , chromosome , botany , toxicity
The publication is the 2-nd and the last part of the review analyzing modern trends of the researches in micronuclear test on human blood lymphocytes, cultivated with cytochalasin B. using data of literature and own results the opportunities of application of the test for study association between parameters of genome instability and genetic polymorphism, adaptive response to gamma-irradiation and emotional stress expression are considered. The analysis of additional capability of the test - frequencies of cells with nuclear buds and nucleoplasmic bridge are presents. Finally, results of the international researches on harmonization of the data of the test and guidelines for evaluation genotoxicity of chemical compounds in vitro are described.