Quality of life and individual susceptibility of human genome. Whether there is an exit from a vicious circle?

The review is devoted to analysis of the connection between parameters of quality of life, state of illness and individual susceptibility of human genome. It is demonstrated, that state of dysadaptation (nonadaptative stress, is describing by H. Selye as reduction of adaptive potential of an organism) for human can be developed both in result of influence of social and/or emotional factors and impact of toxic (genotoxic) chemicals. Using data of literature and results of own studies is shown, that the state of nonadaptive stress is characterized, besides other, an increased genome susceptibility to influence of complex of environmental factors. Thus, in real life is creates «vicious circle» of negative influences on human health: the emotional dysadaptation lead to the perception of social factors pressure as more grinding, what only increases dysadaptation of an organism; thus is creat predisposition to the diseases being the first targets of nonadaptive stress - illnesses of cardiovascular and neuro-immune-endocrinic system, and also to chronic diseases of a gastrointestinal; an action of environmental pollution on a background of the reduced adaptive potential is resulted in increasing of genome instability - therefore the complex of illnesses, including early ageing and cancer, can be developed. For the end are shown the data of literature on the connection between social structure in different countries and state of health of population living in them and is concluded that democratization of a society, respect of human rights and personal freedoms are one of effective ways of an exit from the vicious circle.