Open AccessRole of polymorphism in the CYP1A1, EPHX1, GSTM1, GSTT1 and GSTP1 genes in the development of chronic occupation bronchitis
Author(s) -
Л. З. Ахмадишина,
G. F. Korytina,
Svetlana R Mingazova,
А. Б. Бакиров,
Т. V. Victorova
Publication year - 2005
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen3111-17
Subject(s) - genotype , chronic bronchitis , gstp1 , gene , polymorphism (computer science) , bronchitis , biology , genetics , medicine , gastroenterology
Aim of this study was to investigate the possible roles of metabolic genes polymorphisms in the development and progression of chronic occupation bronchitis. The AG genotype of CYP1A1 gene has associated with increased risk of chronic occupation bronchitis (χ2 = 6,35, p = 0,01). The frequency of GG genotype of GSTP1 gene was significantly higher in patients (8,4% compared to control 2,0%, χ2 = 5,49, p = 0,02). The combination of AA genotype of CYP1A1 and GG genotype of GSTP1 have associated with increased risk of occupation bronchitis (χ2 = 4,66, p = 0,03; OR = 4,21).