Role of polymorphism in the CYP1A1, EPHX1, GSTM1, GSTT1 and GSTP1 genes in the development of chronic occupation bronchitis | Zendy

Л. З. Ахмадишина | Zendy; G. F. Korytina | Zendy; Svetlana R Mingazova | Zendy; А Б Бакиров | Zendy; Т. V. Victorova | Zendy

Open Access

Role of polymorphism in the CYP1A1, EPHX1, GSTM1, GSTT1 and GSTP1 genes in the development of chronic occupation bronchitis

Author(s) -

Л. З. Ахмадишина,

G. F. Korytina,

Svetlana R Mingazova,

А Б Бакиров,

Т. V. Victorova

Publication year - 2005

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen3111-17

Subject(s) - genotype , chronic bronchitis , gstp1 , gene , polymorphism (computer science) , bronchitis , biology , genetics , medicine , gastroenterology

Aim of this study was to investigate the possible roles of metabolic genes polymorphisms in the development and progression of chronic occupation bronchitis. The AG genotype of CYP1A1 gene has associated with increased risk of chronic occupation bronchitis (χ2 = 6,35, p = 0,01). The frequency of GG genotype of GSTP1 gene was significantly higher in patients (8,4% compared to control 2,0%, χ2 = 5,49, p = 0,02). The combination of AA genotype of CYP1A1 and GG genotype of GSTP1 have associated with increased risk of occupation bronchitis (χ2 = 4,66, p = 0,03; OR = 4,21).

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