Open AccessAnalysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people
Author(s) -
Andrey S. Glotov,
Oleg S. Glotov,
М. В. Москаленко,
В. А. Рогозкин,
Т. Э. Иващенко,
Vladislav Baranov
Publication year - 2004
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen2440-43
Subject(s) - genotype , renin–angiotensin system , gene , population , genetics , endocrinology , restriction fragment length polymorphism , polymorphism (computer science) , medicine , ageing , biology , blood pressure , environmental health
We analyzed AGT (M235T), ACE (I/D), AGTR1 (A1166C) genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people by PCR/RFLP methods. It was shown increasing of M/T genotype of AGT gene in rowers compared with population group (46 and 34%, accordantly), I/D of ACE (55 and 48%, accordantly) and decreasing of A/C genotype of AGTR1 gene (38 and 51%). It was detected significantly increasing of M/T genotype of AGT gene elderly people compared with population group (56 and 34%, accordantly, x2=l 1,828, p=0,0006). The received data allow to make the assumption of a possible role renin-angiotensine systems in process of ageing and active physical working capacitу