Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people | Zendy

Аndrey S. Glotov | Zendy; Oleg S. Glotov | Zendy; М. В. Москаленко | Zendy; В. А. Рогозкин | Zendy; Tatyana E Ivashchenko | Zendy; В. С. Баранов | Zendy

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Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people

Author(s) -

Аndrey S. Glotov,

Oleg S. Glotov,

М. В. Москаленко,

В. А. Рогозкин,

Tatyana E Ivashchenko,

В. С. Баранов

Publication year - 2004

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen2440-43

Subject(s) - genotype , renin–angiotensin system , gene , population , genetics , endocrinology , restriction fragment length polymorphism , polymorphism (computer science) , medicine , ageing , biology , blood pressure , environmental health

We analyzed AGT (M235T), ACE (I/D), AGTR1 (A1166C) genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people by PCR/RFLP methods. It was shown increasing of M/T genotype of AGT gene in rowers compared with population group (46 and 34%, accordantly), I/D of ACE (55 and 48%, accordantly) and decreasing of A/C genotype of AGTR1 gene (38 and 51%). It was detected significantly increasing of M/T genotype of AGT gene elderly people compared with population group (56 and 34%, accordantly, x2=l 1,828, p=0,0006). The received data allow to make the assumption of a possible role renin-angiotensine systems in process of ageing and active physical working capacitу

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