The analysis of association between Collal, VDR and CALCR genes and development of osteoporosis | Zendy

М. В. Москаленко | Zendy; М. В. Асеев | Zendy; С. А. Котова | Zendy; В. С. Баранов | Zendy

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The analysis of association between Collal, VDR and CALCR genes and development of osteoporosis

Author(s) -

М. В. Москаленко,

М. В. Асеев,

С. А. Котова,

В. С. Баранов

Publication year - 2004

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen2138-43

Subject(s) - allele , calcitriol receptor , osteoporosis , allele frequency , gene , genetics , biology , population , medicine , polymorphism (computer science) , endocrinology , environmental health

The allele rates of VDR, Collal and CALCR genes in 174 non-related individuals Northwest Russian population and in 70 patients with severe osteoporosis (SO) were investigated by PCR-RFLP method. The frequency of functionally abnormal allele t of VDR gene in a group of SO patients was Sl,4±5,9%, and it was significantly higher (p 0,05) between frequencies of functionally abnormal T allele of CALCR gene in SO (84,4±4,9%) patients and its average frequency in population were recorded (73,8±3,9%). Thus, according to our data clear-cut association between functionally abnormal alleles of VDR and Collal genes and osteoporosis

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