Open AccessThe analysis of association between Collal, VDR and CALCR genes and development of osteoporosis
Author(s) -
М. В. Москаленко,
М. В. Асеев,
С. А. Котова,
Vladislav Baranov
Publication year - 2004
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen2138-43
Subject(s) - allele , calcitriol receptor , osteoporosis , allele frequency , gene , genetics , biology , population , medicine , polymorphism (computer science) , endocrinology , environmental health
The allele rates of VDR, Collal and CALCR genes in 174 non-related individuals Northwest Russian population and in 70 patients with severe osteoporosis (SO) were investigated by PCR-RFLP method. The frequency of functionally abnormal allele t of VDR gene in a group of SO patients was Sl,4±5,9%, and it was significantly higher (p 0,05) between frequencies of functionally abnormal T allele of CALCR gene in SO (84,4±4,9%) patients and its average frequency in population were recorded (73,8±3,9%). Thus, according to our data clear-cut association between functionally abnormal alleles of VDR and Collal genes and osteoporosis