Open AccessSensitive periods in development of endometriosis
Author(s) -
V. S. Baranov,
Баранов Владислав Сергеевич
Publication year - 2018
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen16236-39
Subject(s) - endometriosis , epigenetics , sex organ , mesenchymal stem cell , mullerian ducts , biology , gynecology , infertility , uterus , disorders of sex development , medicine , andrology , pregnancy , endocrinology , gene , genetics
The hypothesis of three sensitive periods (SP) in development of common gynecological disease – external endometriosis (EM) is suggested: I – prenatal female genital system development from the stem cells (SC) of Mullerian ducts; II – uterine endometrial cells transition into mesenchymal meSC; III – endometriotic lesions implantation and growth within pelvic lining. Genetic and epigenetic drivers operative at each SP of EM are outlined and their implication for understanding EM origin and development are briefly discussed.