Sensitive periods in development of endometriosis | Zendy

В. С. Баранов | Zendy

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Sensitive periods in development of endometriosis

Author(s) -

В. С. Баранов

Publication year - 2018

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen16236-39

Subject(s) - endometriosis , epigenetics , sex organ , mesenchymal stem cell , mullerian ducts , biology , gynecology , infertility , uterus , disorders of sex development , medicine , andrology , pregnancy , endocrinology , gene , genetics

The hypothesis of three sensitive periods (SP) in development of common gynecological disease – external endometriosis (EM) is suggested: I – prenatal female genital system development from the stem cells (SC) of Mullerian ducts; II – uterine endometrial cells transition into mesenchymal meSC; III – endometriotic lesions implantation and growth within pelvic lining. Genetic and epigenetic drivers operative at each SP of EM are outlined and their implication for understanding EM origin and development are briefly discussed.

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