Open AccessLong-term gene-environment interactions and genetics of metabolic disorders in aboriginal populations of Northeast Asia
Author(s) -
B. A. Malyarchuk,
Малярчук Борис Аркадьевич
Publication year - 2018
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen16230-35
Subject(s) - trehalase , biology , genetics , polymorphism (computer science) , gene , genetic variation , population genetics , evolutionary biology , genotype , population , enzyme , medicine , biochemistry , environmental health
A review of features of polymorphism of lipid and carbohydrate metabolism genes in aboriginal populations of Siberia is presented. The most significant genetic changes in aboriginal populations of Northeast Asia (Eskimos, Chukchi and Koryaks) are described, related to long-term adaptation to extreme conditions of the natural environment and dietary characteristics. Part of the genetic variability of aboriginal populations of this region is represented by polymorphisms associated with metabolic disorders (deficiency of carnitine palmitoyltransferase 1A, pancreatic amylase, sucrase-isomaltase, trehalase) caused by the change of the traditional protein-lipid diet to “European” carbohydrate one. In modern conditions, it is extremely important to perform large-scale genetic testing of aboriginal populations of the Far North.