The evolution of ideas on the biological role of 5-methylcytosine oxidative derivatives in the mammalian genome | Zendy

Olga A. Efimova | Zendy; Anna A. Pendina | Zendy; Andrei V. Tikhonov | Zendy; В. С. Баранов | Zendy

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The evolution of ideas on the biological role of 5-methylcytosine oxidative derivatives in the mammalian genome

Author(s) -

Olga A. Efimova,

Anna A. Pendina,

Andrei V. Tikhonov,

В. С. Баранов

Publication year - 2016

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen14414-25

Subject(s) - 5 hydroxymethylcytosine , 5 methylcytosine , cytosine , dna , dna methylation , biology , genome , epigenetics , genetics , computational biology , gene , gene expression

Summary: In this review, we summarize data on 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine – cytosine modifications which are produced by TET-mediated oxidation of 5-methylcytosine in DNA. We show the biochemistry of modified cytosine as well as methods for its global and location analysis. We also highlight the milestones in the evolution of ideas on the biological role of 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in the mammalian genome since their discovery in 2009 till present.

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