Open AccessANALYSIS OF ASSOCIATION OF LIPID METABOLISM GENES POLYMORPHISM WITH BMI, WAIST CIRCUMFERENCE AND BLOOD LIPIDOGRAM PARAMETERS IN WOMEN
Author(s) -
Irina V Tarkovskaia,
Oleg S. Glotov,
Ekaterina Y Ditkina,
Elena S. Vashukova,
Andrey S. Glotov,
Roman Vladimirovich Kurilov,
Ирина Владимировна Пугачева,
Olga L Belonog,
Ирина Александровна Махрова,
М. В. Асеев,
Т. Э. Иващенко,
Vladislav Baranov
Publication year - 2012
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen10466-76
Subject(s) - waist , circumference , body mass index , polymorphism (computer science) , medicine , biology , logistic regression , restriction fragment length polymorphism , cholesterol , obesity , genetics , endocrinology , genotype , gene , geometry , mathematics
Using the PCR-RFLP method we have studied polymorphism of 36 genes involved in lipid metabolism in 212 women, residents of the North-West Region of Russia (St. Petersburg), aged 18 to 77. We found an association of polymorphism in several candidate genes with body mass index, waist circumference, total cholesterol level, low density lipoprotein cholesterol level and very low density lipoprotein cholesterol level. We propose a logistic regression model for a primary assessment of these parameters in women based on corresponding genetic markers tests.