Open AccessGenes and enzymes of metabolic activation of xenobiotics in chemical carcinogenesis
Author(s) -
В. В. Худолей
Publication year - 2003
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen1030-35
Subject(s) - carcinogen , biotransformation , xenobiotic , enzyme , carcinogenesis , hydroxylation , biochemistry , isozyme , gene , chemistry , metabolic pathway , biology , genetics
In the initial stage of chemical carcinogenesis the primary key event is metabolic activation of exogenic carcinogenic substances. The main enzymes of carcinogen's biotransformation (microsomal hydroxylation, reactions of conjugation) and genes which controlling the activity of these enzymes, has been characterized. The tissue(organ)specificity of expression of gene products (isoforms of su-perfamilies of CYPs and GSTs, family of NATs) as well as genetic polymorphism of enzymes involving into the biotransformation of carcinogenic xenobiotics were demonstrated