Open AccessGenetic study of motor functions in Drosophila melanogaster
Author(s) -
Sergey A. Fedotov,
Julia V Bragina,
Nataliya G Besedina,
Larisa V. Danilenkova,
Elena A Kamysheva,
Н. Г. Камышев
Publication year - 2012
Publication title -
èkologičeskaâ genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.148
H-Index - 3
eISSN - 2411-9202
pISSN - 1811-0932
DOI - 10.17816/ecogen10151-61
Subject(s) - biology , drosophila melanogaster , genetics , drosophila (subgenus) , cpg site , gene , mutant , courtship , drosophilidae , candidate gene , dna methylation , paleontology , gene expression
To investigate molecular mechanisms of central pattern generators (CPG s) functioning, we carried out a screening of collection of Drosophila P-insertional mutants for strong deviations in locomotion and courtship song. In 21 mutants, the site of the P-insertion was localized by sequencing of the fragments of genomic DNA flanking the P-element. Bioinformational analysis revealed a list of candidate genes, potential players in development and functioning of CPG s. Possible involvement of certain identified genes in rhythmic motor activity is suggested for the first time (CG15630, Map205).