Open AccessTHE DIAGNOSIS OF DRUG TOXIDERMIA BY THE METHOD OF STIMULATED BARIUM SULFATE LUMINOL-DEPENDENT CHEMILUMINESCENCE OF LEUKOCYTES
Author(s) -
Nataliа P. Teplyuk,
Теплюк Н. П,
N. L Shimanovskiy,
Шимановский Н. Л,
A. V Semeykin,
Семейкин А. В,
Z.S. Kadyrova,
Кадырова Зилола Салимовна
Publication year - 2019
Publication title -
rossijskij žurnal kožnyh i veneričeskih boleznej
Language(s) - English
Resource type - Journals
eISSN - 2412-9097
pISSN - 1560-9588
DOI - 10.17816/dv42956
Subject(s) - nimesulide , medicine , drug , ceftriaxone , ibuprofen , amoxicillin , chemiluminescence , gastroenterology , pharmacology , antibiotics , chemistry , organic chemistry , microbiology and biotechnology , biology
Objective. the determination of ibuprofen, paracetamol, nimesulide, amoxicillin, ceftriaxone effect on barium sulfate-stimulated luminol-dependent chemiluminescence of leukocytes (SLHL) in patients with drug toxidermy, which occurred after taking these drugs, and the control group for the selection of the drug for replacement therapy. Material and methods. there were 67 patients (44 women and 23 men) with drug toxidemia. 22.4% patients had drug toxidermia after taking ibuprofen, 20.9% patients had drug toxidermia after taking paracetamol, 19.4% patients had drug toxidermia after taking nimesulide, 20.9% patients had drug toxidermia after taking amoxicillin, 16.4% patients had drug toxidermia after taking ceftriaxone and a control group consisting of 67 people (42 women and 25 men), who previously took these drugs without any adverse reactions. The study participants were aged 18 to 75 years, median 53. Measurement SLHL of leukocytes was performed on the Lum-100 chemiluminometer. The calculations were carried out using the computer program «PowerGraph». Results. during the influence of ibuprofen, paracetamol, nimesulide, amoxicillin, ceftriaxone on the blood of patients with intolerance to these drugs and the control group dose-dependent changes in SLHL were observed. The relative intensity and light sum of blood SLHL in patients were significantly lower than in the control group at all studied drug concentrations (p 0.05). Conclusion. During the influence of ibuprofen, paracetamol, nimesulide, amoxicillin, ceftriaxone on the blood of patients with intolerance to these drugs and the control group, a dose-dependent change in SLHL is observed. The relative intensity and light sum of SLHL blood in patients are significantly lower than that of the control group at all studied concentrations of the drug (p 0.05). The revealed significant differences in SLHL indices allow applying the chemiluminescent method for the diagnosis of intolerance to ibuprofen, paracetamol, nimesulide, amoxicillin, ceftriaxone and for a personalized selection of drugs for replacement therapy.