Open AccessMODERN UNDERSTANDING OF THE STRUCTURE OF SKIN MICROBIOTA IN VARIOUS DERMATOSES
Author(s) -
Ekaterina V. Orlova,
A. S Zybareva,
Л. М. Смирнова,
Lyailya N. Kayumova,
D. M Martynenko
Publication year - 2019
Publication title -
rossijskij žurnal kožnyh i veneričeskih boleznej
Language(s) - English
Resource type - Journals
eISSN - 2412-9097
pISSN - 1560-9588
DOI - 10.17816/dv42944
Subject(s) - microbiome , mechanism (biology) , epidermis (zoology) , inflammation , flora (microbiology) , psoriasis , medicine , immunology , colonization , receptor , microbiology and biotechnology , biology , bacteria , bioinformatics , anatomy , genetics , philosophy , epistemology
The skin ecosystem (microbiome) is a complex environment represented by a diverse community of microorganisms with various mechanisms of interaction with each other and the epidermis. The structure of colonization varies depending on the localization on the skin and environmental changes. There is a complex mechanism of the indirect influence of microorganisms through Toll-like receptors (TLR2) in the skin on the activation of the cascade of reactions leading to the production of antimicrobial peptides. This is the basis for the development of chronic inflammation, provoking mechanisms of carcinogenesis in skin cells. The mechanisms of influence of the commensal flora on the skin condition, the change in its regenerative capabilities have been little studied. Modern ideas about the importance of skin microbiota in the mechanisms of development of frequently occurring dermatoses are presented.