Open AccessTHE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS
Author(s) -
Т. В. Ставенчук,
Elena Kosmachova,
И. А. Шелестова,
А. А. Славинский,
Е. А. Терман,
A. Verevkin,
L.A. Medvedeva,
K.O. Barbuhatty,
З. Г. Татаринцева,
V. A. Porchanov
Publication year - 2017
Publication title -
kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8627
pISSN - 2220-3095
DOI - 10.17816/clinpract8328-33
Subject(s) - endomyocardial biopsy , biopsy , medicine , heart transplantation , graft rejection , heart transplants , lung transplantation , intensive care medicine , transplantation , cardiology
The following article describes tactics of recipient management when a rejection episode of a heart transplant is being suspected. We have discovered some new figures to assess biopsy samples through computerised morphometric study, which can both improve and clarify biopsy results. CD3+ (T-cells) and CD 68+ (macrophages) figures make it possible to determine the extent of transplant rejection in accordance with the International Society for Heart and Lung Transplantation diagnostic criteria (sensitivity 91%, specificity 91%).