THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS | Zendy

T. V. Stavenchuk | Zendy; E. D. Kosmachova | Zendy; I. A. Shelestova | Zendy; A. A. Slavinsky | Zendy; E. A. Terman | Zendy; A. Verevkin | Zendy; L.A. Medvedeva | Zendy; K. O. Barbuhatty | Zendy; З. Г. Татаринцева | Zendy; V. A. Porchanov | Zendy

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THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS

Author(s) -

T. V. Stavenchuk,

E. D. Kosmachova,

I. A. Shelestova,

A. A. Slavinsky,

E. A. Terman,

A. Verevkin,

L.A. Medvedeva,

K. O. Barbuhatty,

З. Г. Татаринцева,

V. A. Porchanov

Publication year - 2017

Publication title -

journal of clinical practice

Language(s) - English

Resource type - Journals

eISSN - 2618-8627

pISSN - 2220-3095

DOI - 10.17816/clinpract8328-33

Subject(s) - endomyocardial biopsy , biopsy , medicine , heart transplantation , graft rejection , heart transplants , lung transplantation , intensive care medicine , transplantation , cardiology

The following article describes tactics of recipient management when a rejection episode of a heart transplant is being suspected. We have discovered some new figures to assess biopsy samples through computerised morphometric study, which can both improve and clarify biopsy results. CD3+ (T-cells) and CD 68+ (macrophages) figures make it possible to determine the extent of transplant rejection in accordance with the International Society for Heart and Lung Transplantation diagnostic criteria (sensitivity 91%, specificity 91%).

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