Open AccessUSE OF AN AQUEOUS SOLUTION «PHOTODITAZIN», COMPLEXED WITH A VARIETY OF POLYMERS FORTHE TREATMENT OF PURULENT WOUNDS OF SOFT TISSUE EXPERIMENT
Author(s) -
A B Solovyeva,
Соловьева Анна Борисовна,
A.L. Spokoyniy,
Спокойный Александр Леонидович,
Tatyana G. Rudenko,
Руденко Татьяна Георгиевна,
А. Б. Шехтер,
Шехтер Анатолий Борисович,
Н. Н. Глаголев,
Глаголев Николай Николаевич,
Н. А. Аксенова,
Аксенова Надежда Анатольевна,
А. В. Баранов,
Баранов Алексей Викторович
Publication year - 2016
Publication title -
kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8627
pISSN - 2220-3095
DOI - 10.17816/clinpract7245-49
Subject(s) - photodynamic therapy , chitosan , polymer , ethylene oxide , poloxamer , propylene oxide , aqueous solution , drug , photosensitizer , copolymer , chemistry , biomedical engineering , materials science , pharmacology , medicine , organic chemistry
The article presents the results of a study of water-soluble polymers effects on the “Photoditazin” activity and the course of wound process under photodynamic therapy of purulent wounds in rats. The data of macroscopic and histological study of wounds status before and after photodynamic therapy, and assessed the quality and degree of intensity of reparative processes under influence of photodynamic therapy with the drug “Photoditazin” and its complexes with water-soluble polymers of natural poly- saccharide chitosan and a triple block copolymer of ethylene- and propylene oxide (pluronic F127).It was given the rationale for Pluronic F127 joining to the drug “Photoditazine” for reducing the cytotoxic effects of the drug.