Open AccessEFFECT OF ANTICANCER DRUGS ON PRIMARY CELL CULTURES OF PATIENTS WITH COLORECTAL CANCER
Author(s) -
N V Golyasnaya,
Yu. V. Ivanov,
N S Zhizhin
Publication year - 2016
Publication title -
kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8627
pISSN - 2220-3095
DOI - 10.17816/clinpract7221-26
Subject(s) - colorectal cancer , cisplatin , cancer research , cytotoxic t cell , fluorouracil , in vitro , cell growth , cell , cancer , pharmacology , cancer cell , oncology , cell culture , chemistry , medicine , biology , genetics , chemotherapy , biochemistry
The goal of the research is to estimate the effect of 5-Fluorouracil, Cisplatin, Tomudex, Leucovorin and their combinations on colorectal cancer cells in vitro. Cell response to the effect of cytotoxic compounds and immunomodulator was estimated by the change in chromosomal aberrations, cell growth rate, proliferative activity and colonyforming unit. It was detected that antineoplastic drugs affected the mutagenesis and fission rate of cultured cells.