Open AccessPROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY
Author(s) -
M. G. Strakhovskaya,
N. S. Belenikina,
В. В. Никитина,
S Yu Kovalenko,
I. B. Kovalenko,
A V Averyanov,
Andrey B. Rubin,
Tatiana Galochkina
Publication year - 2013
Publication title -
kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8627
pISSN - 2220-3095
DOI - 10.17816/clinpract4125-30
Subject(s) - photosensitizer , antimicrobial , photodynamic therapy , chemistry , bacteria , photochemistry , biology , organic chemistry , genetics
A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.