CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE | Zendy

Н. П. Дорофеева | Zendy; С А Плескачев | Zendy; С. В. Шлык | Zendy; E V Tchigaeva | Zendy; E A TherAnanyanz | Zendy; О Г Машталова | Zendy; I E Koulikova | Zendy; А С Плескачев | Zendy; С. С. Тодоров | Zendy

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CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE

Author(s) -

Н. П. Дорофеева,

С А Плескачев,

С. В. Шлык,

E V Tchigaeva,

E A TherAnanyanz,

О Г Машталова,

I E Koulikova,

А С Плескачев,

С. С. Тодоров

Publication year - 2011

Publication title -

journal of clinical practice

Language(s) - English

Resource type - Journals

eISSN - 2618-8627

pISSN - 2220-3095

DOI - 10.17816/clinpract2167-73

Subject(s) - heart failure , decompensation , medicine , cardiology , aldosterone , ischaemic heart disease , genotyping , renin–angiotensin system , myocardial infarction , disease , gene , genotype , blood pressure , biology , biochemistry

Objectives: To investigate genetic and neurohumoral determinants of chronic heart failure (CHF) development and progression in ischaemic heart disease (IHD) patients. Methods: Serum neurohormone level analysis (angiotensin II, aldosterone, endotheline1, NTproBNP, TNFα) and genotyping (genes encoding ACE, angiotensinogen, and type1 angiotensin II receptors ) were implemented in 100 patients Results: Activation of endotheline and NTproBNP is characteristic of early CHF stages while decompensation of chronic heart failure shows elevation in aldosterone and TNFα . Structural polymorphism of renineangiotensine system genes is not significant in CHF development and progression in IHD patients.

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