Open AccessCLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE
Author(s) -
Н. П. Дорофеева,
С А Плескачев,
С. В. Шлык,
E V Tchigaeva,
E A TherAnanyanz,
О Г Машталова,
I E Koulikova,
А. С. Плескачев,
С. С. Тодоров
Publication year - 2011
Publication title -
kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8627
pISSN - 2220-3095
DOI - 10.17816/clinpract2167-73
Subject(s) - heart failure , decompensation , medicine , cardiology , aldosterone , ischaemic heart disease , genotyping , renin–angiotensin system , myocardial infarction , disease , gene , genotype , blood pressure , biology , biochemistry
Objectives: To investigate genetic and neurohumoral determinants of chronic heart failure (CHF) development and progression in ischaemic heart disease (IHD) patients. Methods: Serum neurohormone level analysis (angiotensin II, aldosterone, endotheline1, NTproBNP, TNFα) and genotyping (genes encoding ACE, angiotensinogen, and type1 angiotensin II receptors ) were implemented in 100 patients Results: Activation of endotheline and NTproBNP is characteristic of early CHF stages while decompensation of chronic heart failure shows elevation in aldosterone and TNFα . Structural polymorphism of renineangiotensine system genes is not significant in CHF development and progression in IHD patients.