Open AccessAnalysis of clinikal and morphological features of missed abortions, associated with chromosomal abnormalities of the chorion
Author(s) -
О. А. Романова,
О. А. Романова,
Victoria A. Pechenikova,
Victoria A. Pechenikova,
Т С Карташова,
Т С Карташова,
A S Klyukovkina,
А С Клюковкина,
В. Н. Эллиниди,
В. Н. Эллиниди
Publication year - 2019
Publication title -
vestnik rossijskoj voenno-medicinskoj akademii
Language(s) - English
Resource type - Journals
eISSN - 2687-1424
pISSN - 1682-7392
DOI - 10.17816/brmma25911
Subject(s) - trisomy , miscarriage , aneuploidy , abortion , chromosomal abnormality , obstetrics , products of conception , pregnancy , gynecology , medicine , karyotype , biology , chromosome , genetics , gene
Nowadays the problem of recurrent miscarriage is relevant. 17-20% of all registered pregnancies end with inevitable miscarriages. 80% of them are early pregnancies and in most cases represent missed abortions. Besides, one of the leading cause of missed abortion are chromosomal abnormalities. Analyzed the clinical and anamnestic data of patients, diagnosed with missed abortion during early pregnancy, examined in Saint-Petersburg in 2005-2006 and 2015-2017: patients with normal chorion karyotype and patients with chromosomal abnormalities of the chorion. Revealed that the prevailing chromosomal abnormality is aneuploidy, among all types of aneuploidy the most frequently are trisomy 16, trisomy 13, trisomy 22 and trisomy 21. The structure of aneuploidy has changed in 10-11 years. Now, in comparison with 2005-2006, at missed abortion the trisomy 16 in chorionic villi is found 3.8 times more often, the trisomy 13 is found 2.8 times more often and the trisomy 22 is found twice less often (p