Open AccessDifferential diagnosis of obstetric thrombotic microangiopathy: a review
Author(s) -
Polina I. Kukina,
Кукина Полина Игоревна,
Anastasiya V. Moskatlinova,
Москатлинова Анастасия Витальевна,
И.М. Богомазова,
Irina M. Bogomazova,
Е.В. Тимохина,
Тимохина Елена Владимировна
Publication year - 2021
Publication title -
arhiv akušerstva i ginekologii im. v.f. snegireva
Language(s) - English
Resource type - Journals
eISSN - 2687-1386
pISSN - 2313-8726
DOI - 10.17816/2313-8726-2021-8-2-67-74
Subject(s) - thrombotic microangiopathy , hellp syndrome , medicine , microangiopathic hemolytic anemia , preeclampsia , differential diagnosis , pregnancy , microangiopathy , schistocyte , obstetrics , pediatrics , dermatology , gastroenterology , pathology , thrombotic thrombocytopenic purpura , diabetes mellitus , platelet , endocrinology , disease , biology , genetics
Thrombotic microangiopathy (TMA) is a clinical and morphological syndrome, which is based on damage of the endothelium. Clinically, TMA is characterized by a triad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia, and target organ damage. In obstetric practice, TMA most often occurs with preeclampsia or HELLP syndrome, atypical HUS, TTP. The review presents the basic differential criteria for the diagnosis of TMA during pregnancy and after childbirth, as well as the management of patients.