Open AccessMethods for early diagnosis of Parkinson’s disease
Author(s) -
Maksim B. Kidalov,
Кидалов Максим Борисович,
Elena Savchenko,
Савченко Елена Владиславовна
Publication year - 2020
Publication title -
aspirantskij vestnik povolžʹâ
Language(s) - English
Resource type - Journals
eISSN - 2410-3764
pISSN - 2072-2354
DOI - 10.17816/2072-2354.2020.20.1.62-67
Subject(s) - parkinsonism , disease , motor symptoms , medicine , test (biology) , clinical practice , intensive care medicine , parkinson's disease , physical medicine and rehabilitation , pediatrics , physical therapy , pathology , paleontology , biology
Currently, the diagnosis of Parkinsons disease is carried out mainly on the ground of clinical picture. However, long before the development of motor disorders, a number of signs characteristic of parkinsonism can be detected. The review of the literature presents methods to detect non-motor disorders that can be considered as predictors of the disease and it also discusses the issue of the laboratory studies of specific biomarkers for early diagnosis. We suggested to use the combination of olfactory test and questionnaire about vegetative disorders as the most relevant solution for clinical practice. It is recommended to interpret the test data as a sign of extremely high probability of the development of clinical manifestations of Parkinsons disease, and, therefore, as a reason to start preventive therapy.