Open AccessFetal programming and etiology of osteoporosis
Author(s) -
Wojciech Pieńkowski,
Hubert Wolski,
Krzysztof Drews,
Agnieszka SeremakMrozikiewicz
Publication year - 2015
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.17772/gp/58795
Subject(s) - medicine , osteoporosis , etiology , fetal programming , epidemiology , fetus , epigenetics , bioinformatics , pregnancy , bone density , peak bone mass , skeletal disorder , physiology , pediatrics , intensive care medicine , gene , biochemistry , biology , genetics , chemistry
Osteoporosis is a multifactorial skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, resulting in increased risk of fracture. Peak bone mass is an important predictor of later risk of osteoporosis. Epidemiological studies revealed that the risk of osteoporosis might be modified by exposure to environmental factors during intrauterine life and early postnatal period. This review summarizes the influence of fetal programming on the development of osteoporosis based on the epidemiological studies and potential mechanisms of epigenetic regulation of gene expression.