Open AccessPolymorphism of bone morphogenetic protein (BMP2) and osteoporosis etiology
Author(s) -
Hubert Wolski,
Anna Bogacz,
Joanna BartkowiakWieczorek,
Agnieszka Greber,
Wojciech Pieńkowski,
Krzysztof Drews,
Andrzej Klejewski,
Agnieszka SeremakMrozikiewicz
Publication year - 2015
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.17772/gp/2006
Subject(s) - osteoporosis , osteopenia , medicine , bone morphogenetic protein 2 , genotype , bone remodeling , restriction fragment length polymorphism , bone mineral , bone morphogenetic protein , population , endocrinology , genetics , biology , gene , in vitro , environmental health
Osteoporosis is a chronic, generalized bone disease conditioned by many factors among which the genetic background plays the significant role. Bone morphogenetic protein (BMP2), a growth factor belong to su- perfamily of TNF- proteins, is actively involved in bone tissue metabolism. BMP2 protein shows the osteoinduction potential and regulates growth of cartilage plate, and the same directly influences the process of osteogenesis.