Open AccessVitamin D supplementation attenuates acute inflammatory response
Author(s) -
Jessica Faggion Pinheiro de Oliveira,
Andrieli Cansi,
Bruno Ambrósio da Rocha,
Ciomar Aparecida Bersani-Amado,
Silvana Martins Caparroz-Assef
Publication year - 2020
Publication title -
saúde e pesquisa
Language(s) - English
Resource type - Journals
eISSN - 2176-9206
pISSN - 1983-1870
DOI - 10.17765/2176-9206.2020v13n2p377-387
Subject(s) - medicine , inflammatory response , carrageenan , vitamin , edema , tumor necrosis factor alpha , inflammation , adjuvant , therapeutic effect , dextran , endocrinology , pharmacology , chemistry , biochemistry
This study evaluated the effects of daily vitamin D supplementation on the acute inflammatory response in experimental model by different phlogistic agents: carrageenan, prostaglandin and dextran. Animals (rats) orally received (gavage) a single dose of vitamin D or daily supplementation for 7, 15 or 30 days prior to paw edema induced. Vitamin D supplementation for 15 and 30 days significantly reduced the carrageenan-induced inflammatory process, which could be at least partially explained by the reduction of tumor necrosis factor α levels (TNFα). Results indicate that vitamin D supplementation may be a useful therapeutic adjuvant for controlling the acute inflammatory process.