Open AccessImmunoglobulin A and its selective deficiency
Author(s) -
O.V. Moskalets,
Москалец Оксана Владимировна
Publication year - 2017
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17750/kmj2017-809
Subject(s) - immunology , antibody , immunoglobulin e , primary immunodeficiency , common variable immunodeficiency , asymptomatic , medicine , immunoglobulin g , immunity , immunodeficiency , biology , immune system , pathology
Immunoglobulin A plays a key role in local immunity preventing microorganism adhesion and its activity. Besides, it participates in virus and antigenes neutralizing. In the blood Immunoglobulin A circulates predominantly as a monomer, and at secretion as dimer in complex with S-component. Transitory decrease of Immunoglobulin A develops in different states: infectious and inflammatory processes, allergies, tumors. Specific disease is selective Immunoglobulin A deficiency which is a primary immunodeficiency. It is considered the most prevalent primary immunodeficiency but its true prevalence is unknown as in most cases it is asymptomatic and is revealed accidentally at laboratory testing. No specific methods of treatment of selective Immunoglobulin A deficiency exist. The literature review contains data on the character of the pathology, clinical presentation and tactics of patient management.