Open AccessCharacteristics of endometrial receptivity in women with different endometrial thickness
Author(s) -
Natalia V. Aganezova,
Sergey S. Aganezov,
Ksenia E. Gogichashvili
Publication year - 2022
Publication title -
akušerstvo, ginekologiâ i reprodukciâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 4
eISSN - 2500-3194
pISSN - 2313-7347
DOI - 10.17749/2313-7347/ob.gyn.rep.2022.303
Subject(s) - medicine , endometrium , endometrial biopsy , ovulation , follicular phase , gynecology , estrogen , prospective cohort study , progesterone receptor , estrogen receptor , andrology , endocrinology , hormone , cancer , breast cancer
Aim: to evaluate the expression of estrogen (ER) and progesterone (PR) receptors in the endometrium during the "implantation window" in women with a history of reproductive dysfunction with different endometrial thickness. Materials and Methods. A prospective single-center cohort comparative study was conducted. The main group included patients with hypoplastic ( 0.05). Indicators of endometrial expression of ER, PR, similar to healthy women (n = 16), were found in 21 % (n = 11 out of 52) and 32 % (n = 20 out of 62) in women from main and comparison groups, respectively. The remaining 79 % (n = 41 out of 52) of women with "thin" endometrium (main group) and 68 % (n = 42 out of 62) of patients with normal endometrial thickness (comparison group) had ER and PR expression indices in the endometrial glands and stroma with significant differences (p 0.05) regardless of endometrial thickness. Conclusion. In women with a history of reproductive disorders, parameters of ER and PR expression similar to those in women without reproductive problems, were noted with a "thin" (< 7 mm) endometrium by 50 % less often than those with normal thickness of the uterine mucosa. At the same time, the "thin" endometrium is not an absolute predictor of disorders of the hormone-receptor characteristics of the endometrium: in every fifth case, magnitude of endometrial expression ER, PR similar to healthy women were determined.