Open AccessPlatelets, thrombo-inflammation and cancer
Author(s) -
Е. V. Slukhanchuk,
V. O. Bitsadze,
J. Kh. Khizroeva,
M. V. Tretyakova,
А. Г. Солопова,
В. Н. Галкин,
А. С. Шкода,
В. И. Цибизова,
В. И. Линников,
Ismaı̈l Elalamy,
J.-С. Gris,
Benjamin Brenner,
Alexander Makatsariya
Publication year - 2021
Publication title -
akušerstvo, ginekologiâ i reprodukciâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 4
eISSN - 2500-3194
pISSN - 2313-7347
DOI - 10.17749/2313-7347/ob.gyn.rep.2021.274
Subject(s) - platelet , medicine , hemostasis , metastasis , cancer , thrombosis , inflammation , immune system , platelet activation , cancer cell , tumor microenvironment , cancer research , immunology
It has long been recognized a crucial role played by platelets in thrombosis and hemostasis. Along with that, laboratory and clinical data suggest that platelets contribute to tumor progression and metastasis through a variety of interactions with cancer cells. During oncological process, the platelet function becomes modulated via their activation and increased aggregation being one of the risk factors for developing thrombosis in cancer patients. The platelets per se enhance tumor cell dissemination, activate endothelial cells, and attract immune cells to the primary and metastatic tumor sites. In this review, we summarize the current knowledge about the complex interactions between platelets and tumor cells, as well as cells of the microenvironment, and discuss the development of new antitumor agents aimed at various arms in platelet functioning.