Open AccessThrombophilia in the pathogenesis of fetal growth retardation
Author(s) -
Е. А. Orudzhova,
Natalia Samburova,
E. V. Anichkova,
K. E. Gotsiridze,
Victoria Bitsadze
Publication year - 2021
Publication title -
akušerstvo, ginekologiâ i reprodukciâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 4
eISSN - 2500-3194
pISSN - 2313-7347
DOI - 10.17749/2313-7347/ob.gyn.rep.2021.223
Subject(s) - medicine , thrombophilia , pregnancy , fetus , complication , placenta , pathogenesis , placental insufficiency , placental circulation , obstetrics , fetal growth , in utero , preeclampsia , immunology , thrombosis , genetics , biology
Fetal growth retardation (FGR) is a complication of pregnancy that determines perinatal morbidity and mortality. It is a complex and multifaceted medical problem that does not lose its relevance. Impaired fetal development and delayed growth result from various etiopathogenesis of pathological processes occurring in the "mother–placenta–fetus" interface. Thrombophilia is one of the factors that can initiate disturbed placental function and the utero-placental blood flow. Here we describe the clinical FGR variants and etiopathogenetic factors of developing this complication of pregnancy (placental, maternal, and fetal). Special attention is paid to genetic and acquired thrombophilia (due to the circulation of antiphospholipid antibodies) and their role in development of such complication of pregnancy.