Open AccessConnective tissue dysplasia in the genesis of cervical incompetence
Author(s) -
Е. В. Фотина,
R. R. Zakirova,
М. В. Алексеенкова,
О.Б. Панина
Publication year - 2021
Publication title -
akušerstvo, ginekologiâ i reprodukciâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 4
eISSN - 2500-3194
pISSN - 2313-7347
DOI - 10.17749/2313-7347/ob.gyn.rep.2021.131
Subject(s) - medicine , cervical insufficiency , ctd , etiology , obstetrics , pregnancy , gynecology , dysplasia , cervix , oceanography , cancer , biology , genetics , geology
Aim : to study a role of undifferentiated connective tissue dysplasia (uCTD) in etiology of cervical incompetence and its effect on pregnancy and childbirth course. Material and Methods . There were enrolled 60 patients with cervical incompetence. Patients were divided into 3 groups according to the modified CTD scale: group 1 - patients without uCTD (n = 21); group 2 - patients with mild uCTD (n = 25); group 3 - patients with moderate-to-severe uCTD (n = 14). Intensity of CTD clinical signs was assessed based on health status, gynecological and obstetric history, the course of pregnancy, labor and the postpartum period. Results . It was found that patients with more prominent CTD developed earlier (r-Spearman = -0.26) and more marked (r-Spearman = -0.29) cervical shortening and opening of the internal orifice of the uterus (r-Spearman = 0.28). It was also noted that likelihood of occurring preterm labor was significantly higher in patients with CTD (p = 0.02). Conclusion . The data obtained evidence that uCTD affects intensity of manifested cervical insufficiency and rate of preterm delivery.