Open AccessThe severity of seizures and epileptiform activity index in the assessment of antiepileptic treatment efficacy in patients with generalized tonic-clonic awakening seizures
Author(s) -
В. А. Карлов,
А. Б. Кожокару,
П. Н. Власов,
А. С. Орлова
Publication year - 2021
Publication title -
èpilepsiâ i paroksizmalʹnye sostoâniâ
Language(s) - English
Resource type - Journals
eISSN - 2311-4088
pISSN - 2077-8333
DOI - 10.17749/2077-8333/epi.par.con.2021.091
Subject(s) - epilepsy , seizure types , medicine , anesthesia , antiepileptic drug , electroencephalography , clinical efficacy , pediatrics , psychology , psychiatry
Objective: to evaluate the role of seizure severity and epileptiform activity index (IEA) assessment in newly-diagnosed idiopathic generalized epilepsy with generalized tonic-clonic awakening seizures (GTCS). Material and methods. The study included 31 patients with newly-diagnosed generalized epilepsy with GTCS aged 14–52 years (mean age 25.06±9.3 years), which were divided into two groups depending on seizure severity: Group 1 (n=9, 29%) with 50% (responders), seizure rate decrease by <50% (insufficient efficacy), seizure rate increase and retention in treatment. Results. Total EAI at baseline was significantly higher in patients from Group 2 (p=0.019). Despite markedly reduced EAI level in both groups, in Group 1 (less than 18 points by NHS3) EAI was significantly lower compared to Group 2 (≥18 points) at all subsequent visits: visit 2 (p=0.038), visit 3 (p=0.035), visit 4 (p=0.047), and visit 5 (p=0.022). Conclusions. Assessing seizure severity may become an additional objective criterion while evaluating treatment efficacy.