Open AccessElectroanalysis Of Paracetamol By A Carbon Paste Electrode Modified By Zinc: Analytical Application In Human Blood
Author(s) -
Hayat El Ouafy,
Tarik El Ouafy,
Mustapha Oubenali,
Mohamed Mbarki,
Malika Echajia,
Aziz El Haimouti
Publication year - 2021
Publication title -
metody i obʺekty himičeskogo analiza
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.138
H-Index - 3
eISSN - 2413-6166
pISSN - 1991-0290
DOI - 10.17721/moca.2021.25-31
Subject(s) - zinc , detection limit , electrode , cyclic voltammetry , electrochemistry , carbon paste electrode , voltammetry , chemistry , materials science , nuclear chemistry , analytical chemistry (journal) , inorganic chemistry , chromatography , metallurgy
The present work describes the catalytic effect of zinc particles for electroanalysis the paracetamol (PAR). The working electrode was prepared by mixing the zinc with the carbon powder. The voltammetric behavior of paracetamol was studied when an anodic peak to appear at 0.35 V in 0.1 M Na2SO4 solution (pH 12). The peak resulting from the irreversible oxidation of paracetamol on the zinc modified carbon paste electrode (Zn/CPE). The catalytic effect was evaluated by cyclic voltammetry (CV) and square wave voltammetry (SWV). The electrocatalytic behavior of the zinc particles is allotted to its chemical and physical properties. This electrode has a good performance for the electroanalysis of paracetamol. To obtain an electrochemical analysis of paracetamol oxidation at the surface of Zn/CPE, the voltammograms are used in a potential range of - 1.5 V to 1.5 V. More, Zn/CPE can be utilized successfully to ameliorate the electroanalysis of paracetamol at very feeble concentration and with high detection sensitivity. The limit of detection (LD) and quantification (LQ) obtained are respectively 7.52·10-8 mol L-1 and 2.6·10-7 mol L-1. Then the relative standard deviation (RSD) at 2.0·10-5 mol L-1 PAR concentration was 2.88 % for nine repetitions. Afterward, the presented method was used to electroanalysis paracetamol in human blood samples with satisfying results.