Open AccessSynthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones
Author(s) -
Andrii I. Kysil,
Angelina V. Biitseva,
Oleksandra Bugera,
Tetyana Yegorova,
Zoia Voïtenko
Publication year - 2020
Publication title -
french-ukrainian journal of chemistry
Language(s) - English
Resource type - Journals
ISSN - 2312-3222
DOI - 10.17721/fujcv8i2p176-182
Subject(s) - pharmacophore , chemistry , combinatorial chemistry , oxadiazole , simple (philosophy) , organic chemistry , stereochemistry , philosophy , epistemology
Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.