Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones | Zendy

Andrii I. Kysil | Zendy; Angelina V. Biitseva | Zendy; Oleksandra Bugera | Zendy; Tetyana Yegorova | Zendy; Zoia Voïtenko | Zendy

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Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones

Author(s) -

Andrii I. Kysil,

Angelina V. Biitseva,

Oleksandra Bugera,

Tetyana Yegorova,

Zoia Voïtenko

Publication year - 2020

Publication title -

french-ukrainian journal of chemistry

Language(s) - English

Resource type - Journals

ISSN - 2312-3222

DOI - 10.17721/fujcv8i2p176-182

Subject(s) - pharmacophore , chemistry , combinatorial chemistry , oxadiazole , simple (philosophy) , organic chemistry , stereochemistry , philosophy , epistemology

Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.

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