Open AccessStudy of Calixarene Complexation with Biologically Active
Author(s) -
O. I. Kalchenko,
S. О. Cherenok,
S. Yu. Suikov,
V. I. Kal’chenko
Publication year - 2017
Publication title -
french-ukrainian journal of chemistry
Language(s) - English
Resource type - Journals
ISSN - 2312-3222
DOI - 10.17721/fujcv5i2p49-55
Subject(s) - calixarene , resorcinarene , chemistry , supramolecular chemistry , pyridine , nitrogen atom , molecule , hydrogen bond , oxygen atom , oxygen , cyclophane , medicinal chemistry , stereochemistry , organic chemistry , group (periodic table)
Host-Guest complexation of octakis(diphenoxyphosphoryloxy)tetramethylcalix[4]resorcinarene CRA and 5,17-bis-(N-tolyliminomethyl)-25,27-dipropoxycalix[4]arene CA with bio relevant aromatic, pyridine and diterpenoid carboxylic acids in water-organic solution had been studied by the RP HPLC and molecular modelling methods. The stability constants KA (387-1914 М-1) of the supramolecular complexes had been determined. It was shown the Host-Guest interactions are depended on structure of the Host molecules and log P values of the Guests. The complexation is determined by the hydrogen bonds of the COOH group of the carboxylic acids with P=O oxygen atom of diphenoxyphosphoryl group of the calixresorcinarene CRA, and oxygen or nitrogen atoms located on the lower or the upper rim of the calixarene CA.