Open AccessAntineoplastic, anti-metastatic and metabolic effects of newly synthesized platinum complexes
Author(s) -
A. Biliuk,
L. Garmanchuk,
O. Skachkova,
Hlib Repich,
S. I. Orysyk
Publication year - 2017
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2017.23.69-75
Subject(s) - cisplatin , glutamine , chemistry , cancer research , lactate dehydrogenase , population , lewis lung carcinoma , biochemistry , pharmacology , biology , chemotherapy , microbiology and biotechnology , metastasis , enzyme , medicine , cancer , amino acid , genetics , environmental health
The aim of this work was to study the antitumor, anti-metastatic and metabolic effects of the newly synthesized n, π-chelate complexes Pt2+ with N-allythioureas (complex II and IU complex). The studies used high-metastable strain of transfected Lewis lung carcinoma and HepG2-transformed hepatocyte cells with high activity gamma-glutamate transpeptidases and mouse leukemia cells of L1210 with pronounced aneuploid karyotype and short duplication of population. In the comparative analysis with the classical chemotherapy cisplatin, the II and IV complexes revealed antitumor and anti-metastatic effects and normalization of biochemical disorders, which are confirmed by a decrease in the activity of lactate dehydrogenase and gamma-glutamine transpeptidase, indicating the inhibition of the formation of drug resistance.