Open AccessReaction of lymphoidal organs of rats on the growth of glioma C6
Author(s) -
Ievgeniia V. Opeida,
Mariia Rudyk,
V. Svyatetska,
Larysa Skivka,
Olexander G. Fedorchuk
Publication year - 2017
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2017.22.61-65
Subject(s) - glioma , lymphatic system , spleen , pathology , biology , peripheral , immune system , cancer research , immunology , medicine
The study of the responce of peripheral lymphoid structures to the presence of malignant tumor in the brain offers the challenge for the use of immunotherapeutic approaches for the treatment of this disease. This work was aimed to evaluate weight indices and cellularity of lymphoid organs in rat with C6 glioma. One was found that the growth of glioma is accompanied by changes in the cellularity of the organs of the lymphatic system. The observed changes indicate the likelihood of the presentation of C6 glioma antigens in peripheral lymphoid structures, as well as the negative impact of glioma growth on thymus and spleen homeostasis.