Open AccessCorrection of melanin proteolytic activity upon modeling of alkali burns of the esophagus
Author(s) -
N. M. Chornenka,
K. Valetska,
Ya. Rayetska,
Л. И. Остапченко
Publication year - 2017
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2017.22.53-57
Subject(s) - proteolysis , normalization (sociology) , serine , proteolytic enzymes , esophagus , matrix metalloproteinase , chemistry , peptide hydrolases , biochemistry , pathological , medicine , pathology , enzyme , sociology , anthropology , protease
During the esophageal burns first and second degree, were observed the increase of total proteolytic activity and of the main proteinase (metalloproteinases and serine). Experimental melanin correction at a dose of 0.1 mg / kg contributed to the normalization of the pathological increase of total proteolytic activity and the activity of the main proteinase (metalloproteinases and serine), which indicates the normalization of the proteolysis system.