Open AccessAge-related physiological and biochemical changes in Drosophila grown on alpha-ketoglutarate
Author(s) -
Maria P. Lylyk,
Oksana M. Sorochynska,
O. Maniukh,
Maria M. Bayliak
Publication year - 2017
Publication title -
bulletin of taras shevchenko national university of kyiv series problems of physiological functions regulation
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2017.22.25-31
Subject(s) - senescence , drosophila melanogaster , alpha ketoglutarate , biology , antioxidant , drosophila (subgenus) , alpha (finance) , amino acid , medicine , endocrinology , food science , biochemistry , enzyme , surgery , genetics , construct validity , patient satisfaction , gene
In the work, certain metabolic parameters and parameters of functional senescence were studied in the fruit fly D. melanogaster w1118 males fed with alpha-ketoglutarate (AKG). Dietary increased levels of amino acids and protein in 2-day-old males and levels of triacylglycerols in 24-day-old males with no effect on antioxidant system of males of both age groups. In addition, AKG-supplemented food increased resistance to heat stress but not to oxidants in both age groups and prevented the decline in locomotor activity in middle-aged males.
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