Open AccessOxidation-antioxidant balance in the colon mucosa of rats at different times points after ceftriaxone administration
Author(s) -
Yuliia Holota,
Antonio Bazán,
Ganna Tolstanova
Publication year - 2017
Publication title -
vìsnik. problemi regulâcìï fìzìologìčnih funkcìj/vìsnik kiïvsʹkogo nacìonalʹnogo unìversitetu ìmenì tarasa ševčenka. serìâ: problemi regulâcìï fìzìologìčnih funkcìj
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2017.22.11-15
Subject(s) - thiobarbituric acid , superoxide dismutase , catalase , antioxidant , antibiotics , chemistry , ceftriaxone , medicine , intestinal mucosa , pharmacology , endocrinology , biochemistry , lipid peroxidation
Сeftriaxone administration for 14 days (300 mg/kg, i.m.) increased level of thiobarbituric acid reactive substances and decreased the activity of superoxide dismutase and catalase antioxidant enzymes in the colon mucosa of rats immediately after antibiotics injection. On the 29th day of the experiment (in 14 days after ceftriaxone withdrawal) the level of TBA-active substances still 2.5-fold (P <0.05) exceeded the control value and SOD activity remained below control values to the 72nd day of the experiment. These were accompanied by decreased level of protein thiol groups in 15 and 29 days 1.9-fold (P <0.05) and 1.4-fold (P = 0.08), respectively. Thus antibiotics can lead to long-term oxidative disturbance in the colon mucosa of rats.